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. 2003 Aug;71(8):4544–4553. doi: 10.1128/IAI.71.8.4544-4553.2003

TABLE 3.

HLA class II alleles, BCG scar status, sputum status, treatment duration, PPD-specific expression of various TCR Vβ families, and cytokine expression data in various groups of patients

Groupa Sample no. Identi- fication no. BCG scar status Allelesb
% of TCRC band intensity for the following TCR Vβ familiesc:
No. of TCR Vβ families expressed No. of treatment days % of β-actind
DRB1* DRB1* DQB1* DQB1* 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 22 Gamma interferon IL-4 IL-10
a 1 6758 − 15011 09 0601 BL 9 16 7 7 3 32 27 38 9 6 0 6 31 8 0 0 17 13 21 5 9 17 20 4 0 −4
2 6777 − 08 07 0503 02 49 41 26 27 1 5 14 66 5 0 1 6 15 29 0 4 21 16 8 1 0 14 27 5 0 13
3 6761 − 08 06 0503 0612 15 25 27 9 14 −10 21 12 2 −3 2 3 3 4 4 4 8 13 6 8 8 12 130 70 12 1
4 6792 − 15011 04 0601 0302 7 23 1 1 1 8 2 2 10 0 3 10 8 7 4 3 8 4 5 10 0 10 53 15 0 −7
5 6784 − 15011 15021 0601 0604 3 18 15 10 0 8 0 13 −3 0 0 −2 0 0 0 12 1 −9 8 0 8 165 135 6 −35
6 6775 − 07 15021 0601 03032 11 17 16 0 6 4 5 4 2 0 0 0 8 3 0 0 9 0 0 0 0 7 62 65 −5 −4
7 6782 − 15011 01 0602 0501 4 15 7 4 0 0 0 0 11 0 0 0 7 0 0 0 11 0 0 7 0 6 NAe 57 4 −9
8 6781 − 15011 03 0601 02 6 18 5 0 0 0 6 3 13 0 0 0 0 0 0 0 8 0 0 0 0 6 34 213 10 14
9 6772 − 08 03 0503 02 4 15 2 3 0 −1 −3 −3 35 4 −2 8 −2 0 0 0 41 0 8 12 0 6 66 52 10 20
10 6790 − 15011 BL 0601 BL 1 3 0 1 0 0 9 0 −1 0 0 0 6 0 0 0 0 0 9 16 0 4 30 26 0 0
11 6779 − 15011 04 03032 0602 0 20 3 4 0 4 5 0 0 0 0 0 13 0 0 0 0 0 0 0 0 3 35 112 1 −27
12 6767 − 08 BL 0304 BL −6 22 1 0 3 0 20 0 2 −7 0 0 0 0 0 0 8 0 4 0 0 3 35 130 21 −7
13 6755 − 15011 11 0601 BL 0 10 6 4 0 1 1 1 −4 0 −3 0 2 0 0 0 −5 0 −11 0 0 2 NA 22 2 −3
14 6769 − 11 15021 0601 BL 0 1 −2 2 5 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 2 36 8 0 −29
15 6786 − 15011 06 0602 BL 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 17 63 103 −57
16 6757 − 08 06 0503 BL 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 50 126 21 −109
17 6763 − 08 12 0604 BL −5 −13 −7 −7 −8 −8 −5 −26 −24 0 −6 −13 0 −6 0 0 −16 −5 0 0 0 0 5 156 0 −40
b 1 6756 − BL 01 0604 0501 6 9 6 4 0 0 2 3 11 0 0 10 2 0 0 0 0 0 4 2 0 5 17 432 0 −4
2 6780 − 06 01 0612 0501 0 5 7 4 0 12 12 0 1 1 0 0 0 0 0 0 2 0 0 9 0 5 36 121 4 17
3 6789 − 12 BL 06 03 0 31 6 0 0 −1 0 3 0 0 0 −9 0 0 0 0 0 5 6 0 4 1 103 7 1
4 6766 − 03 BL 0604 BL 0 9 0 0 0 0 0 2 6 0 0 0 −1 0 0 0 4 0 0 2 0 2 180 24 0 −30
5 6771 − 11 01 0503 03032 0 6 2 0 0 0 0 −3 0 0 0 −6 −7 −3 0 6 −18 0 0 −3 0 2 90 14 6 72
6 6785 − 06 01 0503 BL 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 60 21 0 −44
7 6773 − 07 01 02 0501 −1 −1 −6 −8 0 −5 −3 0 −16 −2 0 0 −16 0 0 0 −3 0 0 −3 0 0 NA 288 0 0
8 6760 − 04 12 −1 0 −1 −12 0 −8 −6 −8 −11 0 0 0 −4 0 0 0 0 −1 −3 −6 0 0 210 52 0 −15
9 6770 − 03 11 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 17 281 1 −6
10 6752 − 12 07 0301 BL 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NA 184 0 2
11 6764 − 03 07 02 BL −6 −9 −10 −10 0 −7 −9 −3 −2 0 −2 0 −1 0 0 0 −6 0 0 −7 0 0 5 134 30 −11
12 6787 − 06 BL 0612 BL 0 0 0 1 0 5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NA 19 0 −5
c 1 6799 + 15011 03 0601 02 4 7 5 6 0 −5 0 0 1 0 1 0 5 0 0 0 9 2 0 0 0 5 35 82 0 0
2 6800 + 07 15021 0601 02 0 4 0 0 7 0 0 0 11 0 0 0 0 0 0 0 8 0 5 0 0 4 NA 87 0 0
3 6794 + 15011 BL 0601 0610 −11 5 0 −2 1 0 6 1 1 −11 0 0 −4 −3 0 0 −1 1 4 6 0 3 36 137 0 −20
4 6797 + 15011 04 0601 0302 0 8 0 0 0 0 19 0 0 0 0 0 9 0 0 0 1 0 0 2 0 3 NA 149 13 7
5 6791 + 15011 BL 0601 0502 −6 10 0 −3 −8 4 2 0 12 0 0 4 −11 −4 0 0 −1 0 3 0 0 2 34 280 0 0
6 6776 + 15011 08 0601 0604 0 2 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 180 77 −9 −27
d 1 6798 + 07 BL 02 BL 16 17 20 11 1 15 16 13 3 0 2 3 5 1 0 20 9 11 7 8 14 135 110 0 4
2 6762 + 06 07 0612 BL 5 15 8 0 0 2 3 0 10 0 0 2 11 2 0 0 7 0 0 4 0 6 130 59 0 3
3 6793 + 07 5021 0 10 4 2 4 0 4 3 2 0 0 2 11 2 0 0 6 0 0 4 0 3 22 526 0 0
4 6754 + 0305 0610 4 17 7 0 0 0 0 0 3 0 0 0 0 0 0 0 4 8 0 0 0 3 NA 77 27 35
5 6788 + 0503 0302 −4 14 1 2 0 6 6 −2 −2 0 0 0 2 0 0 0 −1 0 −3 −2 0 3 55 393 37 40
6 6748 + 06 07 06 02 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 75 304 0 0
7 6765 + 04 06 0602 0305 0 0 3 0 0 −2 0 0 2 0 0 0 −1 −4 0 0 0 0 0 5 0 0 NA 155 0 −50
a

Group a, BCG scar negative with HLA high-risk alleles; group b, BCG scar negative with HLA no-risk alleles; group c, BCG scar positive with HLA high-risk alleles; group d, BCG scar positive with HLA no-risk alleles.

b

HLA DRB1*1501, DRB1*08, and DQB1*0601 are high-risk alleles (24).

c

In group a the numbers of responders for TCR Vβ families 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, and 22 were 6, 12, 8, 4, 3, 4, 9, 3, 7, 1, 0, 4, 8, 3, 0, 0, 10, 3, 6, 7, and 2, respectively; in group b the numbers of responders for these families were 1, 5, 3, 0, 0, 1, 2, 0, 2, 0, 0, 1, 0, 0, 0, 1, 0, 0, 0, 2, and 0, respectively; in group c the number of responders for these families were 0, 4, 1, 1, 1, 0, 2, 0, 2, 0, 0, 0, 2, 0, 0, 0, 2, 0, 1, 1, and 0, respectively; and in group d the numbers of responders for these families were 2, 5, 3, 1, 0, 2, 2, 1, 1, 0, 0, 0, 3, 1, 0, 0, 3, 2, 1, 1, and 1, respectively.

d

Data from reference 7.

e

NA, not available.