Table 3.

Ratio of probabilities when the wild type does not replicate

	Probability before	Probability after	Probability after (βwt = 0)	Ratio	Ratio (βwt = 0)
i	0.01	<0.002	0.010	–	1.000
ii	0.02	0.008	0.006	0.400	0.300
iii	0.13	0.042	0.072	0.323	0.554
iv	0.32	0.132	0.396	0.413	1.238
v	0.035	0.232	0.632	0.663	1.806

Results of the simulations showing the effect of total suppression of wild type replication on the probability of emergence of resistance during therapy. The simulations were run at least 100 times for the estimation of probability before therapy and 500 times for the corresponding probability during therapy. Parameters of the simulations are: for i, ii, and iii, γ = 5, R_d = 0.98, R_b = 2, and s = 0.009, s = 0.005, and s = 0.002, respectively; for iv and v, R_d = 0.98, R_b = 10, s = 0.002, and γ = 2, and γ = 1, respectively. Other parameters are in all cases: λ = 10⁶, a = 0.5, δ = a/γ, μ = 3 × 10⁻⁵, n = 3, β_wt = R_d × (aδ/λ), and β_i = (1 − s)β_wt.