TABLE 2.
Lesions and immunolocalization in mice inoculated with 10 TCID50 of C. burnetii
| Organ | SCID mice
|
C.B-17 and A/J micea
|
||
|---|---|---|---|---|
| Lesion | C. burnetiib | Lesion | C. burnetii | |
| Heart | Pancarditis; vacuolated macrophage infiltration, particularly severe in pericardium; focal calcification | ++ | None | − |
| Kidney | Glomerulonephritis; confluence of macrophages in glomeruli and pelvis | ++ | None | − |
| Spleen | Severe splenitis; diffuse replacement by macrophages; many vacuoles | +++ | Focal granulomas | − |
| Liver | Severe hepatitis; diffuse replacement by macrophages; denatured and withered hepatocytes; many vacuoles; megakaryocytes | +++ | Focal granulomas | − |
| Lung | Severe interstitial pneumonia; macrophage infiltration, particularly around the vessels | +++ | Minimal interstitial pneumoniac | − |
a
There was no noticeable difference between the two mouse strains.
b
C. burnetii detection by immunocytochemistry. −, no immunopositive cells in the section; ++, immunopositive cells in a certain part of the section; +++, immunopositive cells throughout section.
c
3 of 6 C.B-17 mice and 3 of 5 A/J mice.