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Anti-tumor activity of IL-1ra gene transduction and over-expression in melanoma xenografts. An IL-1 producing melanoma (SMEL) was mixed at the indicated ratios with the same cell line that was transduced to over-express IL-1ra (SMEL/IL-1ra) ex vivo and injected s.c. into athymic nude mice. There was significant growth inhibition at all tested ratios, indicating a marked paracrine effect of IL-1ra on tumor growth.
