Table 2.

Established anti-tumor activities of IL-1 blocking methods and/or therapies based on published literature.

Study	Year	Observation
Voronov et al [7]	2003	IL-1 KO mice failed to develop solid tumors post injection of melanoma cells and exhibited significantly improved survival compared with wild type animals.
Saijo et al [19]	2002	Overexpression of IL-1 is associated with an aggressive/malignant phenotype.
Sawai et al [22]	2003	Same observation as above
Voronov et al [7]	2003	Same observation as above
Weinreich et al [28]	2003	IL-1ra-transduced xenografts exhibited decreased tumor growth and metastases in murine models.
Elaraj et al [15]	2006	Exogenously administered IL-1ra (anakinra) decreased tumor proliferation rate, metastases, and IL-8 and VEGF mRNA expression of xenografts in murine models.