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Nociceptive responses of WT and PK2-/- mice to thermal stimuli. A, Tail-withdrawal latency from hot and cold water in WT (black bars, n = 9) and PK2-/- mice (white bars, n = 8). PK2-/- mice exhibited significantly increased tail withdrawal latencies than WT controls at 46°C, 48°C and 4°C. B, Paw-withdrawal latency from hot water. PK2-/- mice exhibited significantly increased paw withdrawal latencies than WT controls at 46°C and 48°C. Asterisk, P < 0.05; two asterisks P < 0.01.
