TABLE 3.
Effect of anti-IL10R MAb plus low-dose AMB treatmenta
| Treatment | Low-dose AMB | Liver parasite burden (LDU)
|
% Killing | |
|---|---|---|---|---|
| Day +14 | Day +21 | |||
| None | − | 1,257 ± 55 | 1,236 ± 132 | 0 |
| None | + | 1,078 ± 147 | 15 | |
| Anti-IL-10R | − | 1,058 ± 126 | 16 | |
| Anti-IL-10R | + | 302 ± 90b | 76 | |
| Rat IgG | + | 1,074 ± 99 | 12 | |
| AmB (optimal) | 201 ± 30b | 84 | ||
a
At 12 days after infection, mice received no therapy or a single injection of anti-IL-10R or rat IgG. Low-dose AMB (1 mg/kg) was given on days +14 and +17; optimal AMB (5 mg/kg) was given on days +14, +16, and +18. The results are from two experiments and indicate the means ± standard errors of means for a total of 9 to 11 mice per group at each time point.
b
P < 0.05 the value on day +14.