TABLE 5.
In vivo efficacies of S-3578 and other agents against murine polymicrobial systemic infection caused by methicillin-resistant S. aureus SR17505 and P. aeruginosa SR24a
| Compound | ED50 (mg/kg/dose) | 95% confidence limit (mg/kg/dose) | MICb (μg/ml) |
|---|---|---|---|
| S-3578 | 10.9 | 8.57-13.8 | 4/4 |
| Cefepime | >100 | NCc | >64/1 |
| Ceftazidime | >100 | NC | >64/1 |
| Linezolid | >30 | NC | 2/>128 |
| Vancomycin | >100 | NC | 1/>128 |
| Ceftazidime + vancomycind | 15.1 | 9.98-19.7 |
a
The challenge dose of MRSA SR17505 was 4.9 × 107, and that of P. aeruginosa SR24 was 1.1 × 102.
b
MIC for MRSA/MIC for P. aeruginosa.
c
NC, not calculated.
d
Ceftazidime and vancomycin were used in combination at a ratio of 1:1.