TABLE 6.
Pharmakokinetic parameters for S-3578 and reference drugs in micea
| Compound | C15 (μg/ml) | AUC0-∞ (μg · h/ml) | t1/2 (h) | Excretion (% at 0 to 2 h)
|
|
|---|---|---|---|---|---|
| Urine | Bile | ||||
| S-3578 | 21.6 | 14.7 | 0.26 | 73.2 | 2.9 |
| Cefepime | 26.9 | 11.5 | 0.28 | 80.8 | 1.7 |
| Ceftazidime | 19.1 | 11.4 | 0.25 | 50.4 | 3.1 |
a
Abbreviations: t1/2, half-life; AUC0-∞, area under the concentration-time curve from time zero to infinity; C15, concentration of drug in serum at 15 min. The concentration in plasma was calculated by one-compartment analysis with the WinNonlin program. The plasma and urine were negative for the active metabolite.