TABLE 1.
Viruses against which CV-N was determined to be inactive (no inhibition of virus-induced cytopathicity at 10 μg/ml)
| Virus | Cells for propagation | Virus strain(s) (if applicable) | Virus assay | End point (Antiviral cytotoxicity) |
|---|---|---|---|---|
| HBV | HepG2-2.2.15 | NAa | Real-time PCR | HBV DNA copy number (MTS) |
| HSV-2 | Vero | MS | CPE | MTS |
| HCMVb | MRC-5 | AD169 | CPE | MTS |
| VZV | MRC-5 | Ellen | Plaque reduction | Visual counting (MTS) |
| HHV-8 | BCBL-1 | NA | Real-time PCR | HH-V8 DNA number copy (MTS) |
| Rhinovirus | MRC-5 | 1A, 14, 26, 1B | CPE | MTS |
| RSV | Vero | Long | CPE | MTS |
| Coxsackie A virus | MRC-5 | A21-Kuykendall, A7-275/58 | CPE | MTS |
| Coxsackie B virus | Vero | B3-Nancy, B1-201468 | CPE | MTS |
| Enterovirus | MC-5 | 70 (J670/71) | CPE | MTS |
| Echovirus | MRC-5 | 21 (HA antigen 27513) | CPE | MTS |
| Adenovirus | HeLa | Type 2 | CPE | MTS |
a
NA, not applicable.
b
HCMV, human cytomegalovirus.