TABLE 1.

In vitro activities of mono- and bis-quaternary ammonium salts against P. falciparum (Nigerian strain) and their specificities against PC biosynthesis

Formula	Name	R1	R2	R3	n	IC50 (μM)	PC50 (μM)	PE50 (μM)	NA50 (μM)
R1|R—(CH2)n—N+—R2| R3, Br−	E8a	CH3	CH3	CH3	16	0.8	21	23	44
	E10a	C2H5	C2H5	C2H5	12	0.064	1	22	3.6
	E13a	C3H7	C3H7	C3H7	12	0.033	3	21	2
	F4a	CH3	CH3	CH2— CH2— OH	12	0.48	6.5	28	19
R1   R1   ||R2—N+—(CH2)n—N+—R2   ||    R3R3, 2Br−	G4a	CH3	CH3	CH3	12	0.090	4.8	>20	>200
	G5	CH3	CH3	CH3	16	0.004	0.6	≥100	5
	G12	C2H5	C2H5	C2H5	8	0.540
	G14	C2H5	C2H5	C2H5	12	0.045	7.5	>20	20
	G15	C2H5	C2H5	C2H5	16	0.0016	0.35	100	3
	G19	C2H5	C2H5	C2H5	21	0.000003
	G24	CH3	—(CH2)4—		12	0.013	6.5	>200	>200
	G25	CH3	—(CH2)4—		16	0.00064	0.4	≥100	1.2
		H5	C2H5	C2H5	CH2— CH2— OH	16	0.0049	0.16	2	0.8

^aThese activities have been reported in references 2 and 8.