TABLE 5.
Comparative effects of seven quaternary ammonium compounds on the growth of P. falciparum (IC50), and lymphoblastoid cells (Ly50), macrophages (Ma50), and megakaryoblasts (Mg50)a
| Compound | IC50 (μM) | Ly50 (μM) | Ma50 (μM) | Mg50 (μM) |
|---|---|---|---|---|
| E8 | 0.8 | 14*b | ND | ND |
| E13 | 0.033 | 0.3 | 0.13 | 1.2 |
| F4 | 0.48 | 3.7*b | ND | ND |
| G4 | 0.09 | 95b | ND | ND |
| G12 | 0.54 | 220 | 160 | >300 |
| G19 | 3 × 10−6 | 0.5 | 0.7 | 1.5 |
| H5 | 0.0049 | 20 | 10 | 19 |
a
IC50 against P. falciparum-infected RBC are from Table 1. Ly50, Ma50, and Mg50 were measured after 24 h of drug contact with 6,000 cells/well, as described in Materials and Methods. ND, not determined.
b
These values have already been reported in reference 2.