TABLE 1.

In vivo antimalarial activities and acute toxicity of monoquaternary ammonium salts in mice^a R₁ | R (CH₂)_n—N⁺—R₂, X⁻ | R₃

^aAntimalarial activities were determined after i.p. administration of the compounds once daily for 4 days to infected mice. The first drug administration began 1 h after i.p. inoculation with P. berghei strain NS. TI were calculated on the basis of the acute LD₅₀/ED₅₀ ratios. IC₅₀s were already reported in references 1 and 6. ND, not determined; Ts, tosyl.

^bValues are for in vivo P. berghei per mouse.