TABLE 2.
Clinical outcomes by baseline pathogens at days 21 to 35 in studies of acute otitis media
| Outcome and treatment | Efficacy rate (%) (95% CI) by baseline pathogen
|
Reference or source | |
|---|---|---|---|
| H. influenzae | S. pneumoniae | ||
| Clinical successa | |||
| Azithromycin (5 days) | 64 (50, 78) | 71 (60, 83) | 9 |
| Amoxicillin-clavulanate | 67 (59, 76) | 74 (65, 82) | 4 |
| Clinical cure | |||
| Cefdinir | 62 (47, 78) | 56 (44, 68) | 2 |
| Azithromycin (single dose) | 67 (54, 80) | 88 (81, 94) | Present study |
| Ceftriaxone (3-day, i.m.b dose) | 69 (56, 81) | 81 (70, 92) | 6 |
| Azithromycin (3 days) | 69 (41, 97) | 94 (72, 100) | Arguedas et al.c |
a
Clinical success is defined as cure plus improvement.
b
i.m., intramuscular.
c
4th Int. Conf. Macrolides, Azalides, Streptogrimins, ketobides.