TABLE 3.
MICs of levofloxacin alone and in combination with subinhibitory concentrations of cefotaxime for two penicillin-resistant strains (WB4 and KR4)
| Drug | MIC (mg/liter)a
|
|||||
|---|---|---|---|---|---|---|
| WB4 | WB4 LVX | WB4 LVX + CTX | KR4 | KR4 LVX | KR4 LVX + CTX | |
| Levofloxacin | 1 | 64 | 2 | 1 | 64 | 2 |
| Cefotaxime | 1 | 1 | 1 | 1 | 1 | 1 |
a
WB4, quinolone-susceptible but penicillin-resistant parent pneumococcus (MIC, 4 mg/liter); WB4 LVX, levofloxacin-resistant derivative selected by passages on this drug; KR4, quinolone-susceptible but penicillin-resistant parent pneumococcus (MIC, 4 mg/liter); KR4 LVX, levofloxacin-resistant derivative selected by passages on this drug; WB4 LVX+CTX and KR4 LVX + CTX, same as WB4 LVX and KR4 LVX, respectively, cycled in presence of subinhibitory concentrations of cefotaxime.