TABLE 3.

Mean diameters of P. yoelii yoelii and P. falciparum schizonts in treated and untreated cultures

Compound (μg/ml)	Mean diam (μm)± SD of schizonts in cultures for P. yoelii yoeliic	P value vs controld	Mean diam (μm) ± SD of schizonts in cultures for P. falciparumc	P value vs controld
Control	25.7 ± 7.8		9.0 ± 3.1a/17.7 ± 9.1b
Grepafloxacin
3.125	12.4 ± 3.6	<0.0001	4.1 ± 1.3a	<0.0001
6.25	8.3 ± 8.0	<0.0001	3.6 ± 0.1a	<0.0001
Trovafloxacin
12.5	12.9 ± 5.2	<0.0001	3.7 ± 0.7a	<0.0001
25	9.7 ± 5.0	<0.0001	3.9 ± 1.0a	<0.0001
Piromidic acid
25	9.4 ± 3.8	<0.0001	14.4 ± 3.5b	0.09
50	4.3 ± 1.4	<0.0001	6.3 ± 1.6b	<0.0001

^aAssessment of in vitro activity at 72 h.

^bActivity evaluated at 120 h.

^cMeasurements of 25 schizonts were performed using an immunofluorescence test with an anti-HSPi72 antibody (magnification, ×250).

^dStudent t test; significant for P < 0.05.