TABLE 3.

Effects of salinity on MICs of halocidin congeners, P18, and melittin for antibiotic-resistant bacteria^a

NaCl concn (mM)	MIC (μg/ml)
	MRSA strain:				MDRPA strain:				VRE strain:
	3001	3543	3570	3572	3002	2092	2095	2109	5028	5029
di-18Hc
0	4-8	2-4	2-4	4-8	2-4	2-4	8-16	2-4	2-4	2-4
100	4-8	8-16	2-4	4-8	8-16	2-4	8-16	4-8	2-4	2-4
200	4-8	8-16	2-4	4-8	8-16	2-4	8-16	8-16	2-4	2-4
300	8-16	8-16	2-4	4-8	16-32	2-4	8-16	8-16	2-4	2-4
di-18HcKK
0	8-16	8-16	4-8	4-8	2-4	2-4	4-8	2-4	1-2	1-2
100	16-32	16-32	8-16	8-16	8-16	4-8	4-8	4-8	1-2	1-2
200	32-64	32-64	16-32	16-32	16-32	8-16	8-16	8-16	2-4	2-4
300	>64	>64	16-32	32-64	32-64	8-16	16-32	16-32	2-4	2-4
di-K19Hc
0	2-4	2-4	2-4	4-8	2-4	1-2	4-8	2-4	1-2	1-2
100	2-4	2-4	2-4	4-8	2-4	1-2	4-8	2-4	1-2	1-2
200	2-4	2-4	2-4	4-8	4-8	1-2	4-8	2-4	2-4	2-4
300	4-8	2-4	2-4	4-8	4-8	2-4	4-8	2-4	2-4	2-4
di-K19HcKK
0	4-8	8-16	2-4	8-16	2-4	2-4	4-8	2-4	1-2	1-2
100	16-32	16-32	8-16	16-32	2-4	2-4	4-8	4-8	2-4	1-2
200	32-64	32-64	16-32	>64	4-8	2-4	4-8	4-8	2-4	2-4
300	>64	32-64	32-64	>64	8-16	2-4	4-8	4-8	2-4	2-4
P18
0	4-8	16-32	16-32	8-16	4-8	8-16	2-4	1-2	2-4	4-8
100	32-64	16-32	16-32	>64	4-8	8-16	4-8	4-8	4-8	4-8
200	>64	16-32	>64	>64	8-16	>64	8-16	16-32	>64	>64
300	>64	16-32	>64	>64	16-32	>64	32-64	>64	>64	>64
Melittin
0	1-2	1-2	1-2	1-2	4-8	4-8	4-8	2-4	1-2	1-2
100	2-4	1-2	1-2	1-2	4-8	4-8	4-8	4-8	1-2	1-2
200	2-4	1-2	1-2	1-2	8-16	8-16	8-16	8-16	1-2	1-2
300	2-4	2-4	1-2	1-2	16-32	16-32	16-32	16-32	1-2	1-2

^aBacterial strains were clinically isolated at the Culture Collection of Antibiotic-Resistant Microbes.