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. Author manuscript; available in PMC: 2007 Jan 1.
Published in final edited form as: Neurobiol Dis. 2006 Sep 28;25(1):73–79. doi: 10.1016/j.nbd.2006.08.009

Figure 2.

Figure 2

Effects of administration of exogenous testosterone or its metabolites. The flurothyl seizure threshold was determined for the first clonic seizure in muscimol-infused (normalized to saline-infused) rats at PN15. Muscimol infusions in the SNR had proconvulsant effects in all groups compared to saline infused controls suggesting that exposure to testosterone or its metabolites during the early postnatal period (irrespective to the sex) is responsible for the male proconvulsant phenotype of seizure-controlling SNR effects. The groups included male rats with early life natural testosterone exposure (castrated at PN3; taken from Figure 1), females and males castrated at PN0, which were hormonally treated with TP, DES, or DHT between PN0-PN2.

Inset: For clarity, we included the already published data on SNR muscimol effects on flurothyl-induced seizures in intact males, females, and males castrated at PN0 (Velíšková and Moshé, 2001). These data show that SNR muscimol had a proconvulsant effect in intact males but not in intact females or castrated males at PN0.

An asterisk indicates significant differences (P < 0.05) from respective sex- and treatment specific saline controls.