Table 1.
Mean (± SD) pharmacokinetic parameters of trospium chloride after administration by the intravenous and oral routes (after Guay 2003)
| Populations | N | Dose (mg) | Route | Frequency | Cmax (mg/L) | tmax (h) | AUC (mg/L˙h) | t½ | CL (mL/min) |
|---|---|---|---|---|---|---|---|---|---|
| Healthy younger men | 6 | 0.5 | IV | 1 dose | ND | ND | 7.0 ± 2.2 | 1.6 ± 0.6 | 1405 ± 830a |
| 807 ± 391b | |||||||||
| Healthy elderly men | 18 | 20 | PO | 1 dose | 1.4 ± 88%c | 3.5 ± 77%c | 14.0 ± 79%c | 10.2 ± 47%c | ND |
| 20 | PO | q12 h × 9 | doses 1.9 ± 47%c | 3.2 ± 71%c | 15.0 ± 38%c | 12.7 ± 32%c | ND |
a
Total body clearance.
b
Renal clearance.
c
Percentage coefficient of variation.
Abbreviations: AUC, area under the plasma concentration-versus-time curve; CL, clearance; Cmax, peak plasma concentration; d, days; IV, intravenous; ND, not done; PO, oral; q12h, every 12 hours; tmax, time to Cmax; t ½, terminal disposition half-life.