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Comparative properties of nanoparticle albumin-bound paclitaxel and Cremophor EL-containing paclitaxel
| Nanoparticle albumin-bound paclitaxel (ABI-007) | Cremophor EL-based paclitaxel (eg, Taxol) | |
|---|---|---|
| Hypersensitivity reactions | No | Yes |
| Leaches plasticizers from intravenous tubing | No | Yes |
| Forms micelles in plasma | No | Yes |
| Transported via gp60 receptor on vascular endothelial cells | Yes | No |
| Nonlinear pharmacokinetics | No | Yes |
| Drug–drug interactions | Not known | Yes |
