Table 2.
Summary of noncompartmental pharmacokinetic parameters for paclitaxel following administration of ABI-007; data are presented as mean values (% coefficient of variation)
| Dose (mg/m2) | Infusion duration (min) | Number of patients | Cmax (ng/mL) | AUC∞ (ng · h/mL) | Half-life (h) | CL (L/h ˙ m2) | Vz (L/m2) |
|---|---|---|---|---|---|---|---|
| 135 | 30 | 1 | 6100 | 6427 | 14.6 | 21.1 | 442 |
| 200 | 30 | 3 | 7757 (35) | 9613 (20) | 13.4 (67) | 21.4 (21) | 384 (64) |
| 260 | 30 | 14 | 22969 (113) | 14789 (45) | 21.6(17.2) | 21.1(43.8) | 663.8 (48.1) |
| 300 | 30 | 5 | 13520 (7) | 17610 (21) | 14.6 (14) | 17.7 (22) | 370 (23) |
| 375 | 30 | 4 | 19350 (15) | 35805 (40) | 13.2 (12) | 11.9 (42) | 236 (54) |
Adapted from Hawkins et al (2004) and Ibrahim et al (2002).
Abbreviations: Cmax, peak concentration; AUC∞, area under the concentration-time curve from time 0 to infinity; CL, total body clearance; Vz, volume of distribution.