Table 3.
Summary of pharmacokinetic parameters for paclitaxel following administration of ABI-007 and Taxol; data are presented as mean values (% coefficient of variation)
| Parameter | ABI-007 260mg/m2 | Taxol 175 mg/m2 | p-value |
|---|---|---|---|
| CL (L/h ˙ m2) | 21.13 (43.8) | 14.76 (31.8) | 0.048 |
| Vdss (L/m2) | 230.7 (54.3) | 156.3 (43.2) | 0.211 |
| Vz (L/m2) | 663.8 (48.1) | 433.4 (31.1) | 0.040 |
| AUC∞ (ng ˙ h/mL) | 14 788.6 (45.3) | 12 602.7 (21.0) | 0.524 |
| Cmax (ng/mL) | 22 968.6 (112.5) | 3543.3 (57.2) | < 0.001 |
| tmax (h) | 0.36 (45.2) | 20.14 (55.8) | < 0.001 |
| t½ (h) | 21.6 (17.2) | 20.5 (14.6) | 0.479 |
Data adapted from Hawkins et al (2004).
Abbreviations: CL, total body clearance; Vdss, volume of distribution at steady state; Vz, volume of distribution; AUC∞, area under the concentration-time curve from time 0 to infinity; Cmax, peak concentration; tmax, time to peak concentration; t½, half-life.