Table 2.
Penetration of benzophenone-3 from each of the vehicles studied following application of a finite dose to human epidermis
| Vehicle | |||||
|---|---|---|---|---|---|
| LP | CO | EC | AC | OC | |
| Maximum amount penetrated at 8 h (μg/cm2 ± SEM; n = 6) | 46.6 ± 3.9 | 9.3 ± 0.6 | 22.9 ± 0.9 | 20.9 ± 0.8 | 30.3 ± 2.4 |
| % absorbeda | 9.97 | 1.97 | 4.86 | 4.43 | 6.41 |
| Rs (μg ± SEM) | 9.2 ± 1.9 | 9.5 ± 1.9 | 133.2 ± 19.3 | 9.7 ± 0.8 | 16.1 ± 4.8 |
| % retainedb | 1.94 | 2.00 | 28.22 | 2.04 | 3.42 |
a
Percentage of dose applied penetrating across epidermis to receptor over 8-hour application period.
b
Percentage of dose applied retained in epidermis at 8 hours after application.
Abbreviations: AC, aqueous cream; CO, coconut oil; EC, ethanol:coconut oil; LP, liquid paraffin; OC, oily cream; Rs, amount remaining in epidermis.