Table 2.

Drug–drug interactions observed with azole antifungal drugs and CYP3A4 metabolizing agents

Agent	Indication
Contraindicated
Quinidine	Antimalarial prophylaxis
	Arrythymias
Selected benzodiazapines	Anxiety
Pimozide	Psychotic symptoms
Dofetilide	Arrythmias
Lovastatin, simvastatin, atovastatin	High cholesterol, heart disease
Reported drug–drug interactions
Nifedipine	Hypertension
Potential for drug–drug interactions
Phenytoin	Epilepsy
Astemizole	Allergy
Midazolam	Anxiety
Oral contraceptives	Contraception
Reaglinide, pioglitzone	Diabetes
Cisapride	Poor gastrointestinal motility
Didanosine	HIV
Ritonavir, saquinavir, Amprenavir	HIV
Digoxin	Congestive heart failure
H2 receptor blockers	Dyspepsia, stomach ulcer
Isoniazid	Tuberculosis
Rifampicin	Tuberculosis
Tacrolimus	Transplant recipients
Vincristine	Solid tumors
Warfarin	Anticoagulant