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Properties of duloxetine
| Indication | SUI |
|---|---|
| Mechanism of action: | Dual serotonin and norepinephrine reuptake inhibition leading to increased urethral sphincter activation |
| Dosage and administration: | 40 mg oral twice daily |
| Pharmacokinetic profile: | Cmax: 50 ng/mL, time to Cmax: 6 h, elimination half-life: 12 h |
Abbreviations: Cmax, maximum concentration; h, hours; SUI, stress urinary incontinence.
