Table 1.

Targets of sorafenib in cell-free assays

Kinase	IC50
CRAF	< 10nM
mVEGFR3	10–20 nM
mPDGFR, BRAF, BRAFV600E	20–40 nM
Flt-3, c-KIT	40–80 nM
VEGFR2	80–160 nM
MEK, ERK, EGFR, HER-2	Inactive at 10 000 nM

Abbreviations: EGFR, epidermal growth factor receptor; ERK, extracellular signal-mediated kinase; Flt-3, fetal liver tyrosine kinase 3; HER-2, human epidermal growth factor receptor 2; IC₅₀, concentration of drug required to cause 50% inhibition of an enzyme; m, murine; MEK, mitogen-activated protein kinase kinase; PDGFR, platelet-derived growth factor receptor; VEGFR, vascular endothelial growth factor receptor.