Table 1.

Recommended voriconazole doses for adults (Klasko 2005)

Administration route	FDA-labeled indication	Dose
Intravenous	Invasive aspergillosis, fusariosis, and scedosporiosis (Fusarium spp and Scedosporium apiospermum).	Loading dose 6 mg/kg every 12 hours for two doses, followed 4 mg/kg every 12 hours. Dose may be reduced 3 mg/kg every 12 hours if patient is unable to tolerate treatment.
		Efficacy has been demonstrated with a duration of 6–27 days, then orally for 4–24 weeks in immunocompromised patients with invasive aspergillosis.
	Candida infections.	Loading dose 6 mg/kg every 12 hours for two doses.
		Maintenance dose 3 mg/kg every 12 hours as primary therapy for patients with candidemia or 4 mg/kg every 12 hours in patients with deep-tissue Candida infections (disseminated infections of skin and infections of abdomen, kidney, bladder wall, and wounds).
		Minimum of 14 days following the resolution of symptoms or following the last positive culture.
		If the patient is unable to tolerate treatment, the dose may be reduced 3 mg/kg every 12 hours.
Oral	Esophageal candidiasis.	Weight ≥40 kg (mL oral suspension):
		- Loading dose: 400 mg (10 mL) every 12 hours (for the first 24 hours)
		- Maintenance dose: 200 mg (5 mL) every 12 hours.
		Weight ≤40 kg:
		- Loading dose: 200 mg (5 mL) every 12 hours (for the first 24 hours)
		- Maintenance dose: 100 mg (2.5 mL) every 12 hours.
		Minimum of 7 days.

Abbreviations: FDA, US Food and Drug Administration.