1. Concentrations |
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free BFA in vascular space of compartment i (mol cm-3) |
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free BFA in extravascular space of compartment i (mol cm-3) |
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BFA bound to effector cell (EC) in vascular space of compartment i (mol cm-3) |
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BFA bound to EC extravascular space of compartment i (mol cm-3) |
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EC-BFA complex in vascular space of compartment i (mol cm-3) |
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EC-BFA complex in extravascular space of compartment i (mol cm-3) |
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BFA bound to antigen in vascular space of compartment i (mol cm-3) |
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BFA bound to antigen in extravascular space of compartment i (mol cm-3) |
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captured EC-BFA complex in vascular space of compartment i (mol cm-3) |
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arrested EC-BFA complex in vascular space of compartment i (mol cm-3) |
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EC-BFA complex bound to antigen in vascular space of compartment i (mol cm-3) |
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lymphocyte-BFA complex bound to antigen in extravascular space of compartment i (mol cm-3) |
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nonspecifically bound BFA in vascular space of compartment i (mol cm-3) |
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nonspecifically bound EC-BFA complex in extravascular space of compartment i (mol cm-3) |
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total concentration of cells in vascular space of compartment i (mol cm-3) |
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total concentration of cells in extravascular space of compartment i (mol cm-3) |
2. Kinetic Parameters |
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association constant for binding between BFA and CD3 on EC in compartment i (cm3 mol-1 min-1) |
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dissociation constant for binding between BFA and CD3 on EC in compartment i (min-1) |
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association constant for binding between BFA and antigen in compartment i (cm3 mol-1 min-1) |
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dissociation constant for binding between BFA and antigen in compartment i (min-1) |
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association constant for capture of EC-BFA complex in compartment i (cm3 mol-1 min-1) |
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dissociation constant for capture of EC-BFA complex in compartment i (min-1) |
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rate constant for arrest of EC-BFA complex in compartment i (min-1) |
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association constant for nonspecific binding of BFA in compartment i (min-1) |
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dissociation constant for nonspecific binding of BFA in compartment i (min-1) |
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elimination rate constant for free BFA in kidney (cm3 min-1) |
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elimination rate constant for captured EC-BFA complex in compartment i (min-1) |
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elimination rate constant for arrested EC-BFA complex in compartment i (min-1) |
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transmigration rate constant for arrested EC-BFA complex in compartment i (min-1) |
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transcapillary exchange rate of free BFA in compartment i (mol min-1) |
JS,i |
transcapillary fluid flow rate through small pores in compartment i (cm3 min-1) |
JL,i |
transcapillary fluid flow rate through large pores in compartment i (cm3 min-1) |
JR,i |
fluid recirculation flow rate of compartment i (cm3 min-1) |
P |
baseline production rate of EC in plasma (mol min-1) |
3. Flow Rates |
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Qi |
blood flow into compartment i (cm3 min-1) |
Li |
lymph flow out of compartment i (cm3 min-1) |
Qhepatic |
blood flow into liver before the addition of blood flow from GI and spleen (cm3 min-1) |
4. Volumes |
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VV,i
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vascular volume of compartment i (cm3) |
VEV,i
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extravascular volume of compartment i (cm3) |
5. Other Parameters |
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Fi |
fraction of EC-BFA complex in extravascular space of compartment i that recirculates |
CD |
number of CD binding sites per cell (mol mol-1) |
AV,i
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density of antigen binding sites in the vascular space of compartment i (mol cm-3) |
AEV,i
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density of antigen binding sites in the extravascular space of compartment i (mol cm-3) |
CV,i
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density of capture sites in the vascular space of compartment i (mol cm-3) |
fCDV,i
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density of free CD3 sites in the vascular space of compartment i (mol cm-3) |
fCDEV,i
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density of free CD3 sites in the extravascular space of compartment i (mol cm-3) |
oCDV,i
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density of occupied CD3 sites in the vascular space of compartment i (mol cm-3) |
oCDEV,i
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density of occupied CD3 sites in the extravascular space of compartment i (mol cm-3) |
fCV,i
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density of free capture sites in the vascular space of compartment i (mol cm-3) |
fAV,i
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density of free antigen sites in the vascular space of compartment i (mol cm-3) |
fAEV,i
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density of free antigen sites in the extravascular space of compartment i (mol cm-3) |
PeS,i
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Peclèt number for flow through small pores in compartment i
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PeL,i
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Peclèt number for flow through large pores in compartment i
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ki |
partition coefficient for free BFA between vascular and extra vascular space in compartment i
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PS |
permeability-surface area product (cm3 min-1 g-1) |