Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Proposed mechanism for LpxC. The catalytic zinc ion polarizes a bound solvent molecule, thereby assisting general base E78 in promoting the nucleophilic attack of a water molecule at the scissile amide linkage of the substrate, and it subsequently stabilizes the oxyanion intermediate and its flanking transition states.
