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The active-site loop and important residues involved in the XDH/XO conversion. Differences in active-site structure of the XDH (A) and XO (B) forms are shown. The active-site loop (Gln-423–Lys-433), which moves during the conversion from XDH to XO, is shown in green, and the linker connecting the Mo and FAD domains is shown in orange. Trp-336, which has different configurations in the XDH and XO forms, is shown as a red ball-and-stick model.
