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. 2003 Jun 24;100(14):8281–8286. doi: 10.1073/pnas.1436402100

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Fig. 4. — Aberrant cranial NCC migration and axon pathfinding. Whole-mount in situ hybridization with the NCC marker Sox10 on E8.5 (A and B) and E9 (C and D) embryos revealed aberrant migration of r4-derived NCCs (arrow in B and D) rostrally into mesenchyme adjacent to r3 only in ErbB4^-/- HER4^heart embryos. (E and F) By E11, whole-mount 2H3 antineurofilament immunohistochemistry revealed an ectopic cranial nerve (arrow in F) connecting the geniculate/cochleovestibular (gVII/gVIII) and trigeminal (gV) ganglia in ErbB4^-/- HER4^heart embryos (F). (G) Ectopic nerve fibers are clearly visible (arrows) in a sagittal section through the hindbrain, stained with 2H3 antibody, and detected with a fluorescent secondary antibody. OV, otic vesicle.