Table 2. Characteristics of 30 known genes.
|
Divergence at part of genes
|
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene name | GenBank accession no. | Length sequenced in human, bp | Percentage sequenced in chimpanzee | Overall divergence between human and chimp, % | Promoter, % | Coding, % | Exon-intron junction, % | Nonsynonymous change, no. | Synonymous change, no. | Ka | Ks | Ka/Ks | P* | Divergence at amino acid level, % |
| ADARB1 | AL163301 | 4,826 | 59.10 | 0.60 | 1.07 | 0.08 | 1.11 | 1 | 0 | 0.0006 | 0.0000 | NA | 1.0000 | 0.23 |
| AIRE | AP001754 | 6,393 | 68.37 | 1.17 | 1.72 | 1.01 | 0.63 | 5 | 4 | 0.0047 | 0.0084 | 0.5601 | 0.7078 | 1.68 |
| ATP5A | AP001694 | 2,079 | 100.00 | 1.06 | 0.42 | 1.53 | 1.69 | 0 | 0 | 0.0000 | 0.0000 | NA | 1.0000 | 0.00 |
| B3GALT5 | AL163280 | 3,886 | 63.29 | 1.63 | 1.96 | 1.41 | 2.78 | 6 | 7 | 0.0092 | 0.0225 | 0.4085 | 0.9110 | 1.95 |
| C210RF258 | AP001745-C | 5,402 | 49.44 | 0.82 | NS | 1.22 | 0.59 | 3 | 0 | 0.0036 | 0.0000 | NA | 1.0000 | 0.91 |
| CBR1 | AP001724 | 2,822 | 50.30 | 2.05 | 2.06 | 1.26 | 2.22 | 0 | 5 | 0.0000 | 0.0207 | 0.0000 | 0.9979 | 0.00 |
| CCT8 | AL163249 | 6,213 | 47.48 | 0.64 | 0.16 | 0.42 | 1.43 | 3 | 0 | 0.0062 | 0.0000 | NA | 1.0000 | 1.27 |
| COL6A2 | AP001759 | 2,628 | 73.48 | 0.21 | 0.00 | 0.35 | 0.00 | 4 | 0 | 0.0049 | 0.0000 | NA | 1.0000 | 1.06 |
| CRYAA | AP001748 | 3,235 | 36.75 | 1.43 | 1.75 | 0.48 | 0.83 | 1 | 0 | 0.0066 | 0.0000 | NA | 1.0000 | 1.43 |
| DSCR2 | AL163279-C | 2,886 | 42.69 | 0.89 | 0.63 | 1.32 | 3.36 | 2 | 0 | 0.0014 | 0.0000 | NA | 1.0000 | 0.96 |
| HSF2BP | AP001752-C | 4,793 | 37.03 | 0.73 | 0.78 | 0.96 | 0.51 | 1 | 0 | 0.0015 | 0.0000 | NA | 1.0000 | 2.88 |
| IFNAR1 | AP001716 | 5,421 | 37.63 | 0.88 | 1.24 | 0.69 | 0.41 | 3 | 1 | 0.0024 | 0.0019 | 1.2602 | 0.2459 | 1.54 |
| IFNGR2 | AP001717 | 3,856 | 41.57 | 0.69 | NS | 0.87 | 0.33 | 2 | 2 | 0.0062 | 0.0144 | 0.4322 | 0.6486 | 1.30 |
| KCNE1 | AP001720-C | 2,506 | 67.32 | 1.36 | 1.03 | 2.51 | NS | 6 | 4 | 0.0221 | 0.0303 | 0.7278 | 0.5774 | 4.51 |
| KIAA0539 | AP001713-C | 7,481 | 63.20 | 1.08 | 0.38 | 1.20 | 1.40 | 4 | 12 | 0.0033 | 0.0323 | 0.1031 | 0.3164 | 0.90 |
| MX1 | AL163285 | 8,143 | 66.66 | 0.94 | 0.84 | 0.93 | 1.05 | 6 | 7 | 0.0065 | 0.0146 | 0.4443 | 0.8844 | 1.28 |
| MX2 | AL163285 | 5,949 | 81.74 | 1.32 | 1.76 | 0.74 | 1.43 | 8 | 5 | 0.0071 | 0.0080 | 0.8797 | 0.4859 | 1.37 |
| PCNT | AP001760 | 22,136 | 76.29 | 0.73 | 0.00 | 0.92 | 0.62 | 35 | 37 | 0.0073 | 0.0137 | 0.5280 | 0.9953 | 1.33 |
| PDXK | AP001752 | 5,302 | 47.98 | 1.26 | 1.83 | 0.30 | 0.64 | 1 | 0 | 0.0036 | 0.0000 | NA | 1.0000 | 0.89 |
| PRED14 | AP001679 | 1,456 | 56.80 | 1.45 | 0.24 | 2.52 | NS | 4 | 0 | 0.0343 | 0.0000 | NA | 1.0000 | 7.55 |
| PRED22 | AP001693-C | 5,031 | 74.18 | 0.75 | 0.37 | 0.39 | 1.05 | 2 | 0 | 0.0050 | 0.0000 | NA | 1.0000 | 1.18 |
| PRSS7 | AL163218-C | 2,414 | 74.23 | 0.73 | 0.56 | 0.58 | 1.47 | 2 | 0 | 0.0009 | 0.0000 | NA | 1.0000 | 1.74 |
| SAMSN-1 | AL163206-C | 4,916 | 67.05 | 1.06 | 2.38 | 0.47 | 0.51 | 3 | 1 | 0.0050 | 0.0065 | 0.7732 | 0.0625 | 1.05 |
| SH3BGR | AL163280 | 3,339 | 63.10 | 0.76 | 1.07 | 0.38 | 0.69 | 2 | 0 | 0.0029 | 0.0000 | NA | 1.0000 | 1.13 |
| TFF3 | AP001746-C | 2,946 | 22.57 | 1.50 | NS | 0.60 | 0.98 | 1 | 0 | 0.0056 | 0.0000 | NA | 1.0000 | 1.80 |
| TMPRSS2 | AL163286-C | 6,879 | 59.25 | 0.91 | 0.71 | 0.24 | 1.44 | 2 | 0 | 0.0036 | 0.0000 | NA | 1.0000 | 0.73 |
| TRPC7 | APP001754 | 15,120 | 74.79 | 1.03 | 0.83 | 1.10 | 0.96 | 17 | 19 | 0.0054 | 0.0139 | 0.3912 | 0.9958 | 1.56 |
| TTC3 | AP001728 | 18,213 | 84.85 | 0.67 | 0.70 | 0.36 | 0.88 | 14 | 6 | 0.0040 | 0.0029 | 1.3919 | 0.1820 | 0.76 |
| USP16 | AL163249 | 7,752 | 77.52 | 0.53 | 0.22 | 0.89 | 0.49 | 8 | 6 | 0.0046 | 0.0073 | 0.6245 | 0.7304 | 1.52 |
| WDR4 | AB039887 | 6,097 | 57.68 | 1.02 | 1.07 | 0.36 | 0.73 | 2 | 0 | 0.0039 | 0.0000 | NA | 1.0000 | 1.07 |
NS, no data available because the region was not sequenced; NA, not applicable for calculation
*
P for Ka/Ks = 1 when Ka/Ks ≥ 1