Table 2. Analysis of the degree of the diversity of MBP-reactive TCR Vβ8.2 T cell repertoire among control, EAE, and CD8^-/EAE mice.

Experimental groups	Frequencies of distinct CDR3 sequences that only appear once, %	P	Degree of overall diversity (diversity index*), %	P
Control	57.3 ± 20.1		73.2 ± 16.5
EAE	50.2 ± 4.2	>0.1†	64.8 ± 1.9	>0.1†
CD8-/EAE	18.6 ± 9.4	<0.005‡	36.8 ± 3.6	<0.001‡

Data and statistical analyses were obtained from three separate experiments

^*Diversity index = (the number of distinct CDR3 sequences/total CDR3 sequences obtained) × 100%

^†P value between control group and EAE group

^‡P value between EAE group and CD8^-/EAE group