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Disruption of the nuclear lamina does not block Xic1 destruction. Human LAP2 fragments 1–408 and 1–187 (see Results) were added to Xic1 destruction and replication assays (see Materials and Methods). Destruction activity was defined as the fraction of Xic1 degraded as determined by quantification on the PhosphorImager. Values were normalized to the unperturbed samples.
