Table 2. Pathology in 129/Sv and C57BL/6 recipients of Socs1-/- bone marrow transplants.
|
Percent frequency
|
||||||
|---|---|---|---|---|---|---|
|
129/Sv
|
C57BL/6
|
|||||
| Tissue | Parameter | Socs1-/- (n = 13) | Socs1+/+ or Socs1+/- (n = 20) | Control 129/Sv (n = 7) | Socs1-/- (n = 16) | Socs1+/+ or Socs1+/- (n=24) |
| Liver | Necrosis | 84 | 20 | 29 | 0 | 0 |
| Cuffing of bile ducts | 100 | 40 | 43 | 94 | 13 | |
| Focal granulomas | 100 | 55 | 43 | 93 | 4 | |
| Infiltration, eosinophils | 92 | 45 | 14 | 40 | 4 | |
| Infiltration, plasma cells | 77 | 10 | 0 | 36 | 0 | |
| Excess Kupffer cells | 100 | 25 | 43 | 20 | 4 | |
| Lung | Pneumonia, extensive | 54 | 5 | 14 | 13 | 0 |
| Pneumonia, small foci | 17 | 35 | 29 | 19 | 4 | |
| Cuffing of bronchi or alveolar thickening | 66 | 10 | 29 | 81 | 4 | |
| Foci, eosinophils | 46 | 25 | 29 | 19 | 0 | |
| Foci, plasma cells | 69 | 10 | 0 | 19 | 4 | |
| Foci, lymphocytes | 77 | 15 | 0 | 91 | 79 | |
| Thymus | Atrophy of cortex | 100 | 5 | 0 | 100 | 0 |
| Spleen | Lymphoid follicles | 54 | 100 | 100 | 93 | 100 |
| Naked germinal centers | 33 | 0 | 0 | 0 | 0 | |
| Excess plasma cells | 77 | 5 | 0 | 7 | 0 | |
| Excess hematopoiesis | 85 | 5 | 14 | 40 | 4 | |
| Excess erythropoiesis | 62 | 5 | 57 | 60 | 9 | |
| Excess eosinophils | 50 | 0 | 0 | 13 | 0 | |
| Lymph node | Excess plasma cells | 100 | 7 | 0 | 55 | 9 |
| Bladder | Granuloma | 64 | 0 | 0 | 15 | 19 |
| Kidney | Foci, lymphocytes | 69 | 20 | 0 | 57 | 38 |
| Foci, plasma cells | 62 | 20 | 0 | 21 | 4 | |
| Foci, eosinophils | 15 | 0 | 0 | 0 | 0 | |
| Glomerular tuft thickening | 23 | 5 | 0 | 7 | 0 | |
| Pancreas | Infiltration by macrophages/lymphocytes | 33 | 7 | 0 | 64 | 20 |
| Gut | Granuloma | 67 | 5 | 0 | 50 | 5 |
| Heart | Infiltration | 31 | 11 | 0 | 15 | 0 |
| Salivary gland | Lymphoid foci | 42 | 17 | 14 | 53 | 74 |
| Skin | Epithelial thickening | 31 | 0 | 0 | 13 | 0 |
| Keratin and macrophages | 15 | 0 | 0 | 0 | 0 | |
| Marrow | Excess granulocytes | 100 | 55 | 29 | 81 | 33 |
| Prominent eosinophils | 92 | 40 | 0 | 67 | 0 | |
| Lymphoid leukemia | 0 | 0 | 0 | 6 | 4 | |
| Reticulum cell sarcoma | 0 | 0 | 0 | 6 | 0 | |
n, number of mice examined of each type. Two additional 129/Sv mice grafted with Socs1-/- cells died with failure of engraftment, and their data (hematocrit 10% and 13%, platelets 12, 150, and 9,070 per μl) have been excluded from the table