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Decreases in transcription factor NRF-1 and coactivator PGC1 expression contribute to reductions in oxidative gene expression. (A) Expression of NRF-1 (quantitative PCR), is decreased in DM (*, P = 0.01 vs. FH- controls). (B) PGC1α expression (PCR) is reduced in prediabetic FH+ (34% reduction, P = 0.001 vs. FH-) and DM (36% decrease, P = 0.0009 vs. FH-). (C) PGC1β expression (PCR) is reduced in prediabetic FH+ (45% reduction, P = 0.045 vs. FH-) and DM (46% decrease, P = 0.01 vs. FH-).
