Table 1. Brain regions displaying differential activation between high- and low-sensitivity subgroups.

Region	Coordinates (mediolateral, anterior-posterior, and dorsoventral, mm)	High sensitivity	Low sensitivity	Difference between high-sensitivity and low-sensitivity subgroups
ACC (caudal)	-2, 8, 36	Freq = 6, z = 9.38	Freq = 0, z = NS	Freq = 6*, z = 5.50
ACC (perigenual)	-4, 18, 24	Freq = 5, z = 6.58	Freq = 1, z = 4.8	Freq = 4*, z = 3.2
SI	-4, -34, 58	Freq = 4, z = 7.25	Freq = 0, z = NS	Freq = 4*, z = 4.7
PFC	30, 64, 0	Freq = 4, z = 3.75	Freq = 0, z = NS	Freq = 4*, z = 3.76
PFC	32, 62, -8	Freq = 4, z = 3.80	Freq = 0, z = NS	Freq = 4*, z = 3.4
PFC (ventral)	32, 52, -18	Freq = 4, z = 8.21	Freq = 0, z = NS	Freq = 4*, z = 5.98
Thalamus	-18, -20, 14	Freq = 4, z = 6.85	Freq = 3, z = 9.63	Freq = 1, z = NS

Numbers of subjects (freq) demonstrating significant activation and z-scores (z) of pain intensity-related activation are displayed for high- and low-sensitivity subgroups. Statistically significant differences in the frequency of activation between the high- and low-sensitivity subgroups are defined by Fisher's exact test (P < 0.05, whereas significant activations (or differences) in subgroup analyses were defined by z-scores ≥3.1 and cluster significance of P < 0.005. Nonsignificant functional MRI signal changes are denoted NS

^*, right column