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Development of diet-induced obesity in Foxa-2+/– mice. (a and b) X-gal staining of adipose tissue of wild-type (a) and Foxa-2+/– (b) mice after 6 weeks of a high-fat diet. Absolute weight gain (c), food and water intake (d), heat production (e), resting CO2 production (f), and epidydimal fat pad weight (g) of Foxa-2+/– and wild-type littermates on chow and high-fat diets are shown. *P < 0.05; **P < 0.01.
