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. 2003 Aug;23(16):5540–5555. doi: 10.1128/MCB.23.16.5540-5555.2003

FIG. 6.

FIG. 6.

ΔNp73 compromises p53-dependent apoptosis in primary fibroblasts. (A) 129 wild-type MEFs were infected with the indicated retroviruses 2 days prior to treatment with camptothecin (5 μM for 10 h). (B) 129 wild-type MEFs, p53−/− MEFs, or p73−/− MEFs were infected with the indicated retroviruses 2 days prior to treatment with etoposide (5 μM for 10 h). (A and B) Quantitation of cell death in expressing cells by TUNEL assays. ΔNp73 expression in E1A- or cMyc-sensitized MEFs decreased DNA damage-triggered, p53-mediated apoptosis. The results represent three independent experiments plus the standard deviation. mtΔNp73 stands for ΔNp73 L322P; dnp53 stands for p53 R175H. (C) Representative fields of TUNEL assays from panel B.