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Suppression of HD exon 1 fibril formation by Hsp40 and Hsp70 in vitro. GST-HD fusion protein (3 μM) was incubated with PreScission protease for 5 h as in Fig. 1 in the absence (A) or presence (B–F) of chaperones (6 μM). (B) DnaK; (C) DnaJ; (D) Hdj-1; (E) Hsc70/ATP; (F) Hsc70/Hdj-1/ATP (Hsc70/Hdj-1 = 2:1). Samples then were analyzed by EM. (Bar = 100 nm.)
