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. 2003 Aug;23(16):5857–5866. doi: 10.1128/MCB.23.16.5857-5866.2003

FIG. 1.

FIG. 1.

Hap1 domain structure and schematic diagrams of Hap1 mutants with mutations in or near HRM7. Shown are the C6 zinc cluster motif (Zn), the dimerization element (DE), three repression modules (RPM1 to 3), seven heme-responsive motifs (HRM1 to -6 and HRM7), and the activation domain (ACT). Also shown are the amino acid residues of HRM1 to -7. Mutant H7-1 contains a substitution of the Cys residues in HRM7 with Ala. Mutant H7-N contains a substitution of the HRM7 residues KCPVYQ with residues SGR; mutant H7-N7 contains residues SGRKCPVYQGGR in place of HRM7 residues KCPVYQ; mutant H7-NDH contains residues SGRKCPVDHGGR in place of HRM7 residues KCPVYQ; mutant H7-DH contains residues DH in place of residues YQ in HRM7; mutant H7-10A contains 10 Ala residues inserted in front of HRM7; mutant H7-R2A contains a substitution of the Cys residue at position 1048 in RPM2 with Ala.