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. 2003 Aug;23(16):5614–5624. doi: 10.1128/MCB.23.16.5614-5624.2003

FIG. 5.

FIG. 5.

Histological sections of the heart, bone, brain and renal glomerulus of wild-type (WT) and adam15−/− (−/−) mice. (A to D) Sections of the heart are from E13.5 wild-type (A and C) and adam15−/− (B and D) embryos stained with PECAM-1, a marker for endothelial and endocardial cells (magnification, ×50; scale bar, 500 μm [A and B]; magnification, ×200; scale bar, 100 μm [C and D]). (E and F) Section of the distal femur of 4-week-old wild-type (E) or adam15−/− (F) mice stained with safranin-o (which stains cartilage in red), fast green, and hematoxylin. The overall thickness of the growth plate (GP) and the relative size of the zone of hypertrophic cells (HC) were comparable in wild-type and adam15−/− mice. Scale bar, 500 μm. (G to J) Morphological comparison of the hippocampus (G and H) and cerebellum (I and J) of adult wild-type (G and I) and adam15−/− (H and J) mice stained with cresyl violet. No histological aberrations were apparent in the brains of adam15−/− mice. Scale bar, 500 μm. (K and L) Kidney glomerulus of a wild-type (K) and adam15−/− (L) mouse are indistinguishable from each other at the light-microscopic level at a magnification of ×400. Scale bar, 50 μm.