TABLE 1.
Tumor incidence and histopathology in female MMTV-c-rel transgenic mice after multiple cycles of pregnancy and regressiona
| Mam. tumor diagnosis (other tumors)b | Agec (mo) | No. of:
|
Line | Mouse no.d | |
|---|---|---|---|---|---|
| Mam. tumors | Other tumors | ||||
| Mam. squamous cell carcinoma and hyperplasia (bronchial adenocarcinoma) | 22 | 1 | 1 | 7 | 4026 |
| Mam. adenosquamous carcinoma | 22 | 1 | 0 | 7 | 4042 |
| Mam. adenosquamous carcinoma | 18 | 1 | 0 | 14 | 3814 |
| Mam. adenosquamous carcinoma (papillary bronchial adenomas) | 20 | 1 | 1 | 14 | 3983 |
| Mam. adenocarcinomas with pulmonary metastases | 23 | 4 | 1 | 14 | 3996 |
| Mam. papillary carcinoma, lobular hyperplasia, squamous nodules | 23 | 1 | 0 | 14 | 4936 |
| Mam. squamous cell carcinoma and hyperplasia | 15 | 1 | 0 | 14 | 4556 |
| Mam. adenocarcinoma (papillary bronchial adenocarcinomas) | 19 | 1 | 1 | 15 | 127 |
| Mam. squamous cell carcinoma | 22 | 1 | 0 | 16 | 3872 |
| Mam. adenocarcinoma with poorly differentiated large cells | 18 | 1 | 0 | 16 | 3875 |
| Mam. squamous cell carcinoma and hyperplasia (centrocytic lymphoma) | 18 | 1 | 1 | 16 | 4521 |
| Spindle cell tumor, originating from a mam. adenocarcinoma | 19 | 1 | 0 | 16 | 4528 |
a
Thirty-eight multiparous female mice from the four transgenic lines (7, 14, 15, and 16) were monitored for tumor incidence by biweekly palpable examination.
b
Histopathological analysis of mammary (mam.) glands and other organs (heart, lung, liver, kidney, spleen, and adrenal gland) from the same animal was performed when a tumor was detected.
c
Age when tumor was detected.
d
An identification number was given to the individual mice of the cohort for further analysis of the tumors.