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. 2003 Jun 30;100(15):8670–8675. doi: 10.1073/pnas.1432840100

Fig. 3.

Fig. 3.

Superposition of Kv3 (purple) and Kv4 T1 (green) structures. Only two neighboring subunits of four subunits are shown for clarity. The four-fold symmetry axis is vertical in this view. (a) Two positions (Arg-93 and Ala-63, or Leu-66 and Arg-35) that scored above 2σ for both Kv4 and Kv3, respectively, are labeled with their side chains. Interacting amino acids for Arg-93 are also shown only for Kv4: Asp-88 and Glu-110. Zinc atoms known to be essential for the assembly interface are shown as spheres: Kv3 (red) and Kv4 (yellow). Side chains of three cysteines and one histidine coordinating the zinc are shown only for Kv4 T1. Note that the coordination of zinc is identical by the same set of amino acids: three Cys and one His. (b) Atomic interactions in the region of the MSA position 93 (Arg-93 of Kv4 or Ala-63 of Kv3) are shown. Residue numbers are given for their true amino acid positions. They are Asp-88 and Glu-110 of Kv4 backbone (green) and His-58 and Val-80 of Kv3 backbone (purple).