Figure 4.

Models for SEL-8 function. SEL-8 is a nuclear protein that is required for LIN-12 and GLP-1 signaling. Although several models would be consistent with these basic observations, we feature two here. (A) Scaffold/assembly factor. SEL-8 may serve to stabilize or to facilitate the assembly of a complex that contains LIN-12(intra)/GLP-1(intra) and LAG-1, and perhaps other proteins. (B) Transcriptional activation. The glutamine-rich regions of SEL-8 may function as a transcriptional activation domain that interacts with proteins in the RNA polymerase II transcription initiation complex.