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FLIP analysis of bromodomain point mutants. (A) Bromodomain sequence comparison. (B) Bromodomain point mutants tested in this study. (C) FLIP analysis of mutants tested without (control, Upper) or with (Lower) TSA treatment. T1/2 of M5 and M6 was ≈120 s, whereas that of wild-type Brd4 and other mutants was ≈120 s. None of single point mutants showed a discernible difference in the FLIP pattern (data not shown).
