Figure 5.

dpp signaling is necessary for the spreading of imaginal discs and for filopodia formation. (A and B) The overexpression of UAS-Tkv^DN with Pnr-Gal4 induces a strong cleft phenotype, where heminota are kept well apart (A) but joined by naked cuticle (B). (C and D) The overexpression of UAS-Tkv^DN with MZ980-Gal4 produces a mild cleft phenotype (C). The intervening cuticle shows distinct polarity defects (D). (E) After the overexpression of UAS-Tkv^DN with Pnr-Gal4, filopodia are not present at the leading edge of imaginal tissue (arrowheads), and imaginal cells are pulled together into bunches (arrows).