Table 1. Coincidence of genes encoding calcineurin subunits and calcineurin-interacting proteins with locations of previously identified putative schizophrenia susceptibility loci.
| Gene name | Protein description | Gene location | Susceptibility loci | Refs. |
|---|---|---|---|---|
| Calcineurin subunits | ||||
| PPP3R1 | Calcineurin B subunit | 2p14 | 2p13-14 | 17,21,22 |
| PPP3CA | Calcineurin A α subunit | 4q24 | 4q22-26 | 16,17,23,24 |
| PPP3CC | Calcineurin A γ subunit | 8p21.3 | 8p21-22 | 13-17 |
| PPP3CB | Calcineurin A β subunit | 10q22.3 | 10q22-3 | 25 |
| Calcineurin binding proteins | ||||
| CABIN (=CAIN) | Calcineurin binding protein 1 | 22q11.23 | 22q11 | 2,3 |
| CHP | Calcium binding protein P22 | 15q15.1 | 15q15 | 26 |
| CS-1 (=MYOZZ) | Calcineurin binding protein calsarcin 1 | 4q26 | 4q25-26 | 16,17,23,24 |
| CS-2 (=MYOZ1) | Calcineurin binding protein calsarcin 2 | 10q22.2 | 10q22-3 | 25 |
| CS-3 (=MYOZ3) | Calcineurin binding protein calsarcin 3 | 5q33.1 | 5q33.2 | 16 |
| AKAP5 (=AKAP79) | A kinase (PRKA) anchor protein 5 | 14q23.3 | 14q22-24 | 25,27,28 |
| FKBP5 (=FKBP51) | FK506 binding protein 5 | 6p21.31 | 6p21.3; 6p22-24 | 29-31 |
| Proteins functionally coupled to calcineurin | ||||
| ITPR1 | Inositol 1,4,5-triphosphate receptor, Type 1 (IP3 receptor 1) | 3p26.1 | 3p24-26 | 13 |
| RYR3 | Ryanodine receptor type 3 | 15q13.3-15q14 | 15q14 | 3,32 |
| ILF2 (=NF45) | Subunit of nuclear factor of activated T cells (NFAT) | 1q21.3 | 1q21.3 | 33 |
| CAMLG | Calcium modulating ligand | 5q31.1 | 5q23.3-31.1 | 17,34-36 |
| NFATC2 | Nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 2 | 20q13.2 | 20q13 | 32 |
Gene locations are according to the November 2002 human draft sequence