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. 2003 Jul 9;100(15):9023–9027. doi: 10.1073/pnas.1532244100

Fig. 1.

Fig. 1.

PCNA immunoreactivity is increased in the subependymal layer in HD cases. (a) Table summarizing the age, postmortem delay, pathological grade, CAG trinucleotide repeat length in the IT15 gene, and PCNA grade for each HD case is shown. For each HD case, the level of PCNA immunoreactivity in the subependymal layer was assessed by using a qualitative five-point grading scale (PCNA grade). (b) Compared with the control brain, the thickness of the subependymal layer (SEL) and the number of PCNA+ cells in the SEL are increased as the pathological grade of HD increases (grade 1 to grade 3). In each case, the boundary of the SEL with the caudate nucleus (CN) is indicated by an arrow. (EP, ependymal layer; LV, lateral ventricle). (c) Graph showing a significant correlation between pathological grade and PCNA grade in the HD cases (Spearman rank correlation, r = 0.8972, P ≤ 0.003). (d) Graph showing a significant correlation between CAG trinucleotide repeat length in the IT15 gene and PCNA grade in the HD cases (Spearman rank correlation, r = 0.8168, P ≤ 0.02). (Scale bar, 80 μm.)