Table 2.
The average Mean Cell Survival (MCS) of the 17 LCLs at different drug concentrations, expressed as the Ratio of Maximum Achieved Plasma Concentration (RMAPC)
| 64× dilution | 16× dilution | 4× dilution | 1× no dilution | 64× dilution | 16× dilution | 4× dilution | 1× no dilution | |||
| Group 1 | Vincristine | Epirubicin | ||||||||
| RMAPC | 0.018 | 0.071 | 0.282 | 1.128 | RMAPC | 0.003 | 0.012 | 0.046 | 0.184 | |
| MCS | 81.498 | 46.541 | 20.776 | 18.995 | MCS | 85.206 | 65.736 | 29.435 | 16.306 | |
| SD | 27.995 | 25.737 | 15.258 | 12.209 | SD | 15.548 | 23.394 | 13.593 | 11.314 | |
| Paclitaxel | Methotrexate | |||||||||
| RMAPC | 0.020 | 0.081 | 0.326 | 1.303 | RMAPC | 0.001 | 0.004 | 0.014 | 0.057 | |
| MCS | 48.119 | 29.999 | 24.653 | 23.148 | MCS | 76.618 | 44.824 | 32.924 | 29.314 | |
| SD | 28.435 | 17.418 | 12.869 | 13.364 | SD | 22.796 | 25.843 | 15.590 | 16.455 | |
| Group 2 | Gemcitabin | Dactinomycin | ||||||||
| RMAPC | 0.035 | 0.140 | 0.561 | 2.242 | RMAPC | 0.066 | 0.262 | 1.050 | 4.200 | |
| MCS | 49.354 | 38.411 | 27.808 | 23.784 | MCS | 86.206 | 54.700 | 20.520 | 16.465 | |
| SD | 34.718 | 30.034 | 16.945 | 12.153 | SD | 16.701 | 22.386 | 13.642 | 8.370 | |
| 5-Flurouracil | Vinorelbine | |||||||||
| RMAPC | 0.012 | 0.047 | 0.188 | 0.752 | RMAPC | 0.156 | 0.625 | 2.501 | 10.005 | |
| MCS | 74.861 | 58.001 | 42.337 | 30.505 | MCS | 82.833 | 42.823 | 25.176 | 24.683 | |
| SD | 23.686 | 22.987 | 21.370 | 20.645 | SD | 18.131 | 23.930 | 16.506 | 14.634 | |
| Doxorubicin | Daunorubicin | |||||||||
| RMAPC | 0.028 | 0.112 | 0.447 | 1.789 | RMAPC | 0.133 | 0.531 | 2.126 | 8.502 | |
| MCS | 82.503 | 52.477 | 28.292 | 11.499 | MCS | 83.171 | 61.159 | 25.940 | 20.439 | |
| SD | 21.753 | 24.867 | 22.314 | 10.301 | SD | 21.886 | 25.402 | 23.933 | 17.961 | |
| Etoposide | Docetaxel | |||||||||
| RMAPC | 0.130 | 0.521 | 2.083 | 8.333 | RMAPC | 0.260 | 1.042 | 4.166 | 16.665 | |
| MCS | 56.281 | 35.375 | 25.315 | 16.778 | MCS | 32.990 | 23.036 | 23.866 | 26.331 | |
| SD | 21.045 | 19.983 | 15.497 | 11.166 | SD | 22.690 | 17.587 | 16.810 | 19.810 | |
| Group 3 | Cytarabine | 6-Mercaptopurine | ||||||||
| RMAPC | 0.121 | 0.482 | 1.929 | 7.716 | RMAPC | 0.543 | 2.170 | 8.680 | 34.720 | |
| MCS | 87.321 | 79.450 | 48.255 | 40.124 | MCS | 84.450 | 78.834 | 62.325 | 55.419 | |
| SD | 17.396 | 22.850 | 26.423 | 26.315 | SD | 22.147 | 16.514 | 29.820 | 32.858 | |
| Oxaliplatin | Cladribine | |||||||||
| RMAPC | 0.020 | 0.081 | 0.325 | 1.301 | RMAPC | 0.366 | 1.462 | 5.850 | 23.399 | |
| MCS | 87.951 | 84.477 | 83.331 | 73.511 | MCS | 102.832 | 101.241 | 72.497 | 52.237 | |
| SD | 21.010 | 26.545 | 21.839 | 30.744 | SD | 8.130 | 11.160 | 26.804 | 29.545 | |
| Asparaginase | Chlorambucil | |||||||||
| RMAPC | 0.015 | 0.058 | 0.232 | 0.930 | RMAPC | 2.646 | 10.586 | 42.342 | 169.370 | |
| MCS | 92.021 | 91.570 | 90.371 | 82.978 | MCS | 89.903 | 71.879 | 13.225 | 11.099 | |
| SD | 13.718 | 13.222 | 18.153 | 15.919 | SD | 17.578 | 26.506 | 10.994 | 7.527 | |
| Cyclophosphamide | Topotecan | |||||||||
| RMAPC | 0.014 | 0.056 | 0.224 | 0.896 | RMAPC | 6.194 | 24.777 | 99.107 | 396.429 | |
| MCS | 86.670 | 93.412 | 89.498 | 84.041 | MCS | 93.897 | 72.802 | 23.250 | 24.784 | |
| SD | 21.910 | 18.833 | 17.832 | 17.920 | SD | 19.406 | 21.275 | 16.659 | 21.380 | |
| Ifosphamide | Carboplatin | |||||||||
| RMAPC | 0.009 | 0.037 | 0.147 | 0.588 | RMAPC | 2.814 | 11.257 | 45.027 | 180.108 | |
| MCS | 92.729 | 95.906 | 90.101 | 88.518 | MCS | 91.805 | 79.175 | 77.962 | 52.322 | |
| SD | 16.694 | 14.965 | 15.299 | 16.677 | SD | 16.670 | 30.927 | 22.065 | 31.295 | |
| Hydroxyurea | Bleomycin | |||||||||
| RMAPC | 0.031 | 0.124 | 0.496 | 1.984 | RMAPC | 2.078 | 8.311 | 33.245 | 132.979 | |
| MCS | 95.118 | 96.489 | 86.340 | 68.134 | MCS | 90.007 | 88.553 | 82.168 | 69.803 | |
| SD | 19.595 | 13.933 | 19.759 | 24.782 | SD | 19.294 | 17.678 | 19.720 | 16.686 | |
| Vinblastine | Streptozotocin | |||||||||
| RMAPC | 2.603 | 10.413 | 41.650 | 166.600 | RMAPC | no Cmax data was found | ||||
| MCS | 81.507 | 53.331 | 28.885 | 21.323 | MCS | 95.430 | 92.335 | 89.919 | 87.805 | |
| SD | 25.921 | 25.678 | 17.941 | 15.889 | SD | 15.828 | 18.710 | 14.094 | 22.637 | |
| Bortezomib | MG-132 | |||||||||
| RMAPC | 0.162 | 0.648 | 2.590 | 10.361 | RMAPC | not used in clinical practice | ||||
| MCS | 93.119 | 81.671 | 75.498 | 28.700 | MCS | 87.345 | 96.374 | 88.097 | 27.045 | |
| SD | 13.779 | 21.572 | 19.617 | 26.948 | SD | 13.980 | 17.493 | 16.974 | 24.310 | |
| Prednisolone | ||||||||||
| RMAPC | 4.8 | 19.23077 | 76.92308 | 307.6923 | ||||||
| MCS | 75.55877 | 76.25595 | 62.46537 | 37.23379 | ||||||
| SD | 4.647172 | 11.09091 | 13.97021 | 11.65414 | ||||||
Group 1. Highly effective drugs: RMAPC < 0.3; MCS < 30%
Group 2. Partially effective drugs: RMAPC between 0.3 and 1, MCS < 60%
Group 3. Ineffective drugs: RMAPC > 1 or MCS > 60%
SD: standard deviation in mean cell survival